Device for Injection of Biological Materials

Reference number 8873

Sectors: Cell Therapy

Industries: 3D Bioprinting, Biotechnology

The invention introduces an injector to reduce the damage to biological materials such as cells during an injection process and improve the survivability of the biological materials. Cell survivability is a common problem after injections through small bore needles. The injector creates a two layer concentric flow, with the inner fluid being a hydrogel suspension containing cells or biological materials and the outer fluid being a saline solution to minimise the shear rate experienced by the cells suspended in the hydrogel.

Proposed Use

The goal of this device is to enable cell therapy with direct injection to be more effective. It can eventually be paired with a multitude of cell therapies, e.g., it will provide a better chance of recovery than just rehabilitation for ischemic stroke patients and its implementation with knee OA stem cell therapy would reduce the medical dependence on total knee replacements.

Problem Addressed

Cell injection through a small bore needle remains a challenge due to the high shear rate of the flow, leading to a significant rate of cell mortality. Cell viability rates are as low as 5% after injection. This hinders the effectiveness of cell therapies, in which small bore needles are required to reach many target therapeutic regions. This invention is a novel injection device that reduces mechanical injury that causes cell death and aims to increase efficacy of cell therapies.

Technology Overview

The cell injector is developed by a team led by Prof James Moore Jr. This device maximises cell viability by avoiding the mechanical conditions that kill cells going through a small bore needle. Specifically, the syringe is designed to deliver the two fluids in a concentric manner into the needle at a velocity and radial extents such that the cells suspended in the
hydrogel are protected from potentially damaging high shear rates.

Benefits

  • Predicted to increase acute cell viability to 95%
  • Can be paired with cell therapies and improve the efficacy of treatments

Intellectual Property Overview

This technology is covered by a patent: WO2022/263797A1 INJECTION DEVICE FOR INJECTION OF BIOLOGICAL MATERIALS

Inventor

Professor James Moore Jr

The Bagrit & RAEng Chair in Medical Device Design
Faculty of Engineering, Department of Bioengineering

Visit personal site

Contact us about this technology


Contact

Diana Yin

Industry Partnerships and Commercialisation Executive, Engineering

Diana supports and leads on the commercialisation of MedTech, and HealthTech related technologies from Imperial’s Faculty of Engineering

Contact Diana

[email protected]

Related technologies

Device for Injection of Biological Materials

Device for Injection of Biological Materials

An injector to reduce the damage to biological materials such as cells during an injection process and improve the survivability of the biological materials Find out more

Sign up for updates

Sign up for monthly technology alerts via email, and find other ways to connect with us.

Loading...