A universal method to enhance control of gene expression in vivo with artificial gene-regulatory transcription factors (TFs).
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Therapeutics
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A cytokine for wound healing and scar reduction
A cytokine that promotes wound healing by accelerating re-epithelialization of the wound bed faster than FDA approved products. The treatment also has a potential to minimise scarring after injury.
Dr Claire Higgins
Professor Andrew Rice
Human monoclonal antibodies to COVID-19
A suite of broad neutralising monoclonal antibodies (bnMABs) isolated to be used for treatment of coronaviruses with a focus on SARS-CoV-2 (2019-nCoV).
First-in-class drug candidate for treatment of multiple myeloma and Diffuse Large B Cell Lymphoma
DTP3 is a first-in-class GADD45β/MKK7 inhibitor targeting the NF-κB pathway
Professor Guido Franzoso
Octreotate Radioligand for Imaging Neuroendocrine Tumors
18F-FET-βAG-TOCA is a novel, ‘click’ 18F-labelled octreotate PET imaging radiopharmaceutical that detects tumour lesions in patients with neuroendocrine tumours (NETs).
Professor Eric Aboagye
High-resolution transcription start site mapping using nanogram-levels of total RNA immunoprecipitation (SLIC-CAGE)
A novel development of the cap-trapper CAGE protocol which can generate complex high-quality libraries for as little as 5-10 nanograms of cellular RNA.
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