MicroRNA are important gene regulators and their expression profiles change with pathophysiology, allowing their use as biomarkers. Imperial researchers have identified differential markers that can distinguish pregnancy of unknown location (PUL).
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Zinc finger therapy for Amyotrophic lateral sclerosis (ALS) and Frontotemporal dementia (FTD)
A zinc finger to target both the ALS and FTD therapeutically
Zinc finger therapy for Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS)
A zinc finger (zf) to target the FXTAS mutation therapeutically
Active delivery of Zinc Fingers for in vivo enhancement of gene regulation
A universal method to enhance control of gene expression in vivo with artificial gene-regulatory transcription factors (TFs).
CHORDs – Construction of highly ordered repetitive DNA sequences
CHORDS is a dual clustered regularly interspaced short palindromic repeats (CRISPR)/Golden gate assembly method for the construction of repetitive DNA sequences. This enables the construction of repetitive DNA sequences flanked by short (<30 base pairs) variable DNA regions. This strategy makes it possible to assemble and express guide RNA to be used in CRISPR mediated genetic modification.
First-in-class drug candidate for treatment of multiple myeloma and Diffuse Large B Cell Lymphoma
DTP3 is a first-in-class GADD45β/MKK7 inhibitor targeting the NF-κB pathway
Professor Guido Franzoso
Octreotate Radioligand for Imaging Neuroendocrine Tumors
18F-FET-βAG-TOCA is a novel, ‘click’ 18F-labelled octreotate PET imaging radiopharmaceutical that detects tumour lesions in patients with neuroendocrine tumours (NETs).
Professor Eric Aboagye
High-resolution transcription start site mapping using nanogram-levels of total RNA immunoprecipitation (SLIC-CAGE)
A novel development of the cap-trapper CAGE protocol which can generate complex high-quality libraries for as little as 5-10 nanograms of cellular RNA.
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