…the process, guide RNAs are used to direct CRISPR/Cas9 to cleave specific complimentary strands of DNA within an organism. The expression of synthetic guide RNA is a significant challenge. Whilst…
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Improved Mycobacterial Tetracycline Inducible Vectors
…study. Problem addressed There is a lack of genetic tools available to researchers to study the function of essential mycobacterial genes, we have therefore constructed a range of improved tetracycline…
Novel vortex laser
…the efficiency of laser manufacturing processes, provide advantages in free-space communications being more robust to atmospheric turbulence and offer improved data encryption. Problem addressed Relatively little progress has been made…
Seismic Metamaterials
…implement because they involve the modification of the building itself. Our invention provides a solution to this problem: Shielding vulnerable structures using large-scale metamaterials which inhibit the propagation of incoming…
Novel inhibitor of neuropathic pain
…effects compared to small molecules Intellectual property information Patents: US9718879, EP2807191 Link to published paper Chen, Y. C., Pristerá, A., Ayub, M., Swanwick, R. S., Karu, K., Hamada, Y., Rice…
Human monoclonal antibodies to COVID-19
A suite of broad neutralising monoclonal antibodies (bnMABs) isolated to be used for treatment of coronaviruses with a focus on SARS-CoV-2 (2019-nCoV). Four potential human monoclonal antibodies have been identified…
Machine learning tool stratifying early and late Alzheimer’s disease (ApV)
…undiagnosed in 3 out of 4 people. A battery of tests with variable sensitivity including cognitive, neuropsychological, imaging and laboratory tests are required in combination to make a diagnosis of…
First-in-class drug candidate for treatment of multiple myeloma and Diffuse Large B Cell Lymphoma
…Preclinical work has been completed, showing efficacy, specificity and tolerability, with wide safety margins. In a proof-of-concept Phase I study, DTP3 induced markers for apoptosis in malignant CD138+ cells, but…
Two-gene signature diagnostic test for differentiating between viral and bacterial infections in children
…from viral infection and other common causes of fever in children, which can form the basis of a diagnostic test. Problem addressed Numerous attempts have been made to improve the…
Two distinct late stage preclinical lead series of highly specific inhibitors of MAP4K4
…MAP4K4 inhibitors can be commercialized to be used for protective agents against anthracycline therapy-induced cardiotoxicity. Additionally, MAP4K4 is a pivotal mediator of a number of key pathways and a target…
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